Platelet progenitors: the hidden drug target
نویسندگان
چکیده
منابع مشابه
Platelet progenitors: the hidden drug target.
Platelets are central players in haemostasis and atherothrombosis. Their nucleated progenitors, the megakaryocytes (MKs), reside in the bone marrow and have unique features. During differentiation, MKs first undergo a series of endomitoses, accumulating DNA up to 64–128n in a single cell; thus, mature MKs are the largest bone marrow cells, with a characteristic hyperthrophic nucleus and oversiz...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2015
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehv366